LymphedemaV1, Main, Exploration, bibRecord, 000805

Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.

Identifieur interne : 000805 ( Main/Exploration ); précédent : 000804; suivant : 000806

Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.

Auteurs : Heinrich Schlums [Suède] ; Moonjung Jung [États-Unis] ; Hongya Han [Suède] ; Jakob Theorell [Suède] ; Venetia Bigley [Royaume-Uni] ; Samuel C C. Chiang [Suède] ; David S J. Allan [États-Unis] ; Jan K. Davidson-Moncada [États-Unis] ; Rachel E. Dickinson [Royaume-Uni] ; Tim D. Holmes [Suède] ; Amy P. Hsu [États-Unis] ; Danielle Townsley [États-Unis] ; Thomas Winkler [États-Unis] ; Weixin Wang ; P L Aukrust [Norvège] ; Ingvild Nord Y [Norvège] ; Katherine R. Calvo ; Steve M. Holland [États-Unis] ; Matthew Collin [Royaume-Uni] ; Cynthia E. Dunbar [États-Unis] ; Yenan T. Bryceson [Suède]

Source :

Blood [ 1528-0020 ] ; 2017.

RBID : pubmed:28209719

Descripteurs français

English descriptors

KwdEn :
- Adolescent, Adult, Calmodulin-Binding Proteins (genetics), Calmodulin-Binding Proteins (immunology), Cell Proliferation, Child, Female, GATA2 Transcription Factor (genetics), GATA2 Transcription Factor (immunology), Hematopoietic Stem Cells (immunology), Humans, Interleukin-12 (genetics), Interleukin-12 (immunology), Interleukin-18 (genetics), Interleukin-18 (immunology), Killer Cells, Natural (immunology), Male, Middle Aged, Mutation, RNA-Binding Proteins (genetics), RNA-Binding Proteins (immunology), Receptors, IgE (genetics), Receptors, IgE (immunology), Syk Kinase (genetics), Syk Kinase (immunology), Transcription Factors (genetics), Transcription Factors (immunology).
MESH :
- chemical , genetics : Calmodulin-Binding Proteins, GATA2 Transcription Factor, Interleukin-12, Interleukin-18, RNA-Binding Proteins, Receptors, IgE, Syk Kinase, Transcription Factors.
- chemical , immunology : Calmodulin-Binding Proteins, GATA2 Transcription Factor, Interleukin-12, Interleukin-18, RNA-Binding Proteins, Receptors, IgE, Syk Kinase, Transcription Factors.
- immunology : Hematopoietic Stem Cells, Killer Cells, Natural.
- Adolescent, Adult, Cell Proliferation, Child, Female, Humans, Male, Middle Aged, Mutation.

Abstract

Heterozygous GATA2 mutation is associated with immunodeficiency, lymphedema, and myelodysplastic syndrome. Disease presentation is variable, often coinciding with loss of circulating dendritic cells, monocytes, B cells, and natural killer (NK) cells. Nonetheless, in a proportion of patients carrying GATA2 mutation, NK cells persist. We found that peripheral blood NK cells in symptomatic patients uniformly lacked expression of the transcription factor promyelocytic leukemia zinc finger (PLZF), as well as expression of intracellular signaling proteins FcεRγ, spleen tyrosine kinase (SYK), and EWS/FLI1-Activated Transcript 2 (EAT-2) in a variegated manner. Moreover, consistent with an adaptive identity, NK cells from patients with GATA2 mutation displayed altered expression of cytotoxic granule constituents and produced interferon-γ upon Fc-receptor engagement but not following combined interleukin-12 (IL-12) and IL-18 stimulation. Canonical, PLZF-expressing NK cells were retained in asymptomatic carriers of GATA2 mutation. Developmentally, GATA-binding protein-2 (GATA-2) was expressed in hematopoietic stem cells, but not in NK-cell progenitors, CD3(-)CD56(bright), canonical, or adaptive CD3(-)CD56(dim) NK cells. Peripheral blood NK cells from individuals with GATA2 mutation proliferated normally in vitro, whereas lineage-negative progenitors displayed impaired NK-cell differentiation. In summary, adaptive NK cells can persist in patients with GATA2 mutation, even after NK-cell progenitors expire. Moreover, our data suggest that adaptive NK cells are more long-lived than canonical, immunoregulatory NK cells.

DOI: 10.1182/blood-2016-08-734236
PubMed: 28209719

Affiliations:

Le document en format XML

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<author><name sortKey="Davidson Moncada, Jan K" sort="Davidson Moncada, Jan K" uniqKey="Davidson Moncada J" first="Jan K" last="Davidson-Moncada">Jan K. Davidson-Moncada</name>
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<author><name sortKey="Dickinson, Rachel E" sort="Dickinson, Rachel E" uniqKey="Dickinson R" first="Rachel E" last="Dickinson">Rachel E. Dickinson</name>
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<author><name sortKey="Aukrust, P L" sort="Aukrust, P L" uniqKey="Aukrust P" first="P L" last="Aukrust">P L Aukrust</name>
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<author><name sortKey="Nord Y, Ingvild" sort="Nord Y, Ingvild" uniqKey="Nord Y I" first="Ingvild" last="Nord Y">Ingvild Nord Y</name>
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<author><name sortKey="Bryceson, Yenan T" sort="Bryceson, Yenan T" uniqKey="Bryceson Y" first="Yenan T" last="Bryceson">Yenan T. Bryceson</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.</title>
<author><name sortKey="Schlums, Heinrich" sort="Schlums, Heinrich" uniqKey="Schlums H" first="Heinrich" last="Schlums">Heinrich Schlums</name>
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<country xml:lang="fr">Suède</country>
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<author><name sortKey="Jung, Moonjung" sort="Jung, Moonjung" uniqKey="Jung M" first="Moonjung" last="Jung">Moonjung Jung</name>
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<author><name sortKey="Han, Hongya" sort="Han, Hongya" uniqKey="Han H" first="Hongya" last="Han">Hongya Han</name>
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<author><name sortKey="Theorell, Jakob" sort="Theorell, Jakob" uniqKey="Theorell J" first="Jakob" last="Theorell">Jakob Theorell</name>
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<author><name sortKey="Bigley, Venetia" sort="Bigley, Venetia" uniqKey="Bigley V" first="Venetia" last="Bigley">Venetia Bigley</name>
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<author><name sortKey="Chiang, Samuel C C" sort="Chiang, Samuel C C" uniqKey="Chiang S" first="Samuel C C" last="Chiang">Samuel C C. Chiang</name>
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<country xml:lang="fr">Suède</country>
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<author><name sortKey="Allan, David S J" sort="Allan, David S J" uniqKey="Allan D" first="David S J" last="Allan">David S J. Allan</name>
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<author><name sortKey="Davidson Moncada, Jan K" sort="Davidson Moncada, Jan K" uniqKey="Davidson Moncada J" first="Jan K" last="Davidson-Moncada">Jan K. Davidson-Moncada</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
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<author><name sortKey="Dickinson, Rachel E" sort="Dickinson, Rachel E" uniqKey="Dickinson R" first="Rachel E" last="Dickinson">Rachel E. Dickinson</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Holmes, Tim D" sort="Holmes, Tim D" uniqKey="Holmes T" first="Tim D" last="Holmes">Tim D. Holmes</name>
<affiliation wicri:level="3"><nlm:affiliation>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hsu, Amy P" sort="Hsu, Amy P" uniqKey="Hsu A" first="Amy P" last="Hsu">Amy P. Hsu</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Townsley, Danielle" sort="Townsley, Danielle" uniqKey="Townsley D" first="Danielle" last="Townsley">Danielle Townsley</name>
<affiliation wicri:level="2"><nlm:affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Winkler, Thomas" sort="Winkler, Thomas" uniqKey="Winkler T" first="Thomas" last="Winkler">Thomas Winkler</name>
<affiliation wicri:level="2"><nlm:affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Weixin" sort="Wang, Weixin" uniqKey="Wang W" first="Weixin" last="Wang">Weixin Wang</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD; and.</nlm:affiliation>
<wicri:noCountry code="subField">MD; and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Aukrust, P L" sort="Aukrust, P L" uniqKey="Aukrust P" first="P L" last="Aukrust">P L Aukrust</name>
<affiliation wicri:level="3"><nlm:affiliation>Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nord Y, Ingvild" sort="Nord Y, Ingvild" uniqKey="Nord Y I" first="Ingvild" last="Nord Y">Ingvild Nord Y</name>
<affiliation wicri:level="3"><nlm:affiliation>Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Calvo, Katherine R" sort="Calvo, Katherine R" uniqKey="Calvo K" first="Katherine R" last="Calvo">Katherine R. Calvo</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine, National Institutes of Health Clinical Center, Bethesda, MD; and.</nlm:affiliation>
<wicri:noCountry code="subField">MD; and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Holland, Steve M" sort="Holland, Steve M" uniqKey="Holland S" first="Steve M" last="Holland">Steve M. Holland</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Collin, Matthew" sort="Collin, Matthew" uniqKey="Collin M" first="Matthew" last="Collin">Matthew Collin</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne</wicri:regionArea>
<wicri:noRegion>Newcastle upon Tyne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dunbar, Cynthia E" sort="Dunbar, Cynthia E" uniqKey="Dunbar C" first="Cynthia E" last="Dunbar">Cynthia E. Dunbar</name>
<affiliation wicri:level="2"><nlm:affiliation>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bryceson, Yenan T" sort="Bryceson, Yenan T" uniqKey="Bryceson Y" first="Yenan T" last="Bryceson">Yenan T. Bryceson</name>
<affiliation wicri:level="3"><nlm:affiliation>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Calmodulin-Binding Proteins (genetics)</term>
<term>Calmodulin-Binding Proteins (immunology)</term>
<term>Cell Proliferation</term>
<term>Child</term>
<term>Female</term>
<term>GATA2 Transcription Factor (genetics)</term>
<term>GATA2 Transcription Factor (immunology)</term>
<term>Hematopoietic Stem Cells (immunology)</term>
<term>Humans</term>
<term>Interleukin-12 (genetics)</term>
<term>Interleukin-12 (immunology)</term>
<term>Interleukin-18 (genetics)</term>
<term>Interleukin-18 (immunology)</term>
<term>Killer Cells, Natural (immunology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>RNA-Binding Proteins (genetics)</term>
<term>RNA-Binding Proteins (immunology)</term>
<term>Receptors, IgE (genetics)</term>
<term>Receptors, IgE (immunology)</term>
<term>Syk Kinase (genetics)</term>
<term>Syk Kinase (immunology)</term>
<term>Transcription Factors (genetics)</term>
<term>Transcription Factors (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Cellules souches hématopoïétiques (immunologie)</term>
<term>Cellules tueuses naturelles (immunologie)</term>
<term>Enfant</term>
<term>Facteur de transcription GATA-2 (génétique)</term>
<term>Facteur de transcription GATA-2 (immunologie)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Facteurs de transcription (immunologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Interleukine-12 (génétique)</term>
<term>Interleukine-12 (immunologie)</term>
<term>Interleukine-18 (génétique)</term>
<term>Interleukine-18 (immunologie)</term>
<term>Mutation</term>
<term>Mâle</term>
<term>Prolifération cellulaire</term>
<term>Protéines de liaison à l'ARN (génétique)</term>
<term>Protéines de liaison à l'ARN (immunologie)</term>
<term>Protéines de liaison à la calmoduline (génétique)</term>
<term>Protéines de liaison à la calmoduline (immunologie)</term>
<term>Récepteurs aux IgE (génétique)</term>
<term>Récepteurs aux IgE (immunologie)</term>
<term>Syk kinase (génétique)</term>
<term>Syk kinase (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Calmodulin-Binding Proteins</term>
<term>GATA2 Transcription Factor</term>
<term>Interleukin-12</term>
<term>Interleukin-18</term>
<term>RNA-Binding Proteins</term>
<term>Receptors, IgE</term>
<term>Syk Kinase</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Calmodulin-Binding Proteins</term>
<term>GATA2 Transcription Factor</term>
<term>Interleukin-12</term>
<term>Interleukin-18</term>
<term>RNA-Binding Proteins</term>
<term>Receptors, IgE</term>
<term>Syk Kinase</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de transcription GATA-2</term>
<term>Facteurs de transcription</term>
<term>Interleukine-12</term>
<term>Interleukine-18</term>
<term>Protéines de liaison à l'ARN</term>
<term>Protéines de liaison à la calmoduline</term>
<term>Récepteurs aux IgE</term>
<term>Syk kinase</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules souches hématopoïétiques</term>
<term>Cellules tueuses naturelles</term>
<term>Facteur de transcription GATA-2</term>
<term>Facteurs de transcription</term>
<term>Interleukine-12</term>
<term>Interleukine-18</term>
<term>Protéines de liaison à l'ARN</term>
<term>Protéines de liaison à la calmoduline</term>
<term>Récepteurs aux IgE</term>
<term>Syk kinase</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Hematopoietic Stem Cells</term>
<term>Killer Cells, Natural</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Cell Proliferation</term>
<term>Child</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Enfant</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mutation</term>
<term>Mâle</term>
<term>Prolifération cellulaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Heterozygous GATA2 mutation is associated with immunodeficiency, lymphedema, and myelodysplastic syndrome. Disease presentation is variable, often coinciding with loss of circulating dendritic cells, monocytes, B cells, and natural killer (NK) cells. Nonetheless, in a proportion of patients carrying GATA2 mutation, NK cells persist. We found that peripheral blood NK cells in symptomatic patients uniformly lacked expression of the transcription factor promyelocytic leukemia zinc finger (PLZF), as well as expression of intracellular signaling proteins FcεRγ, spleen tyrosine kinase (SYK), and EWS/FLI1-Activated Transcript 2 (EAT-2) in a variegated manner. Moreover, consistent with an adaptive identity, NK cells from patients with GATA2 mutation displayed altered expression of cytotoxic granule constituents and produced interferon-γ upon Fc-receptor engagement but not following combined interleukin-12 (IL-12) and IL-18 stimulation. Canonical, PLZF-expressing NK cells were retained in asymptomatic carriers of GATA2 mutation. Developmentally, GATA-binding protein-2 (GATA-2) was expressed in hematopoietic stem cells, but not in NK-cell progenitors, CD3(-)CD56(bright), canonical, or adaptive CD3(-)CD56(dim) NK cells. Peripheral blood NK cells from individuals with GATA2 mutation proliferated normally in vitro, whereas lineage-negative progenitors displayed impaired NK-cell differentiation. In summary, adaptive NK cells can persist in patients with GATA2 mutation, even after NK-cell progenitors expire. Moreover, our data suggest that adaptive NK cells are more long-lived than canonical, immunoregulatory NK cells.</div>
</front>
</TEI>
<affiliations><list><country><li>Norvège</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Maryland</li>
<li>Svealand</li>
<li>Østlandet</li>
</region>
<settlement><li>Oslo</li>
<li>Stockholm</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Calvo, Katherine R" sort="Calvo, Katherine R" uniqKey="Calvo K" first="Katherine R" last="Calvo">Katherine R. Calvo</name>
<name sortKey="Wang, Weixin" sort="Wang, Weixin" uniqKey="Wang W" first="Weixin" last="Wang">Weixin Wang</name>
</noCountry>
<country name="Suède"><region name="Svealand"><name sortKey="Schlums, Heinrich" sort="Schlums, Heinrich" uniqKey="Schlums H" first="Heinrich" last="Schlums">Heinrich Schlums</name>
</region>
<name sortKey="Bryceson, Yenan T" sort="Bryceson, Yenan T" uniqKey="Bryceson Y" first="Yenan T" last="Bryceson">Yenan T. Bryceson</name>
<name sortKey="Chiang, Samuel C C" sort="Chiang, Samuel C C" uniqKey="Chiang S" first="Samuel C C" last="Chiang">Samuel C C. Chiang</name>
<name sortKey="Han, Hongya" sort="Han, Hongya" uniqKey="Han H" first="Hongya" last="Han">Hongya Han</name>
<name sortKey="Holmes, Tim D" sort="Holmes, Tim D" uniqKey="Holmes T" first="Tim D" last="Holmes">Tim D. Holmes</name>
<name sortKey="Theorell, Jakob" sort="Theorell, Jakob" uniqKey="Theorell J" first="Jakob" last="Theorell">Jakob Theorell</name>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="Jung, Moonjung" sort="Jung, Moonjung" uniqKey="Jung M" first="Moonjung" last="Jung">Moonjung Jung</name>
</region>
<name sortKey="Allan, David S J" sort="Allan, David S J" uniqKey="Allan D" first="David S J" last="Allan">David S J. Allan</name>
<name sortKey="Davidson Moncada, Jan K" sort="Davidson Moncada, Jan K" uniqKey="Davidson Moncada J" first="Jan K" last="Davidson-Moncada">Jan K. Davidson-Moncada</name>
<name sortKey="Dunbar, Cynthia E" sort="Dunbar, Cynthia E" uniqKey="Dunbar C" first="Cynthia E" last="Dunbar">Cynthia E. Dunbar</name>
<name sortKey="Holland, Steve M" sort="Holland, Steve M" uniqKey="Holland S" first="Steve M" last="Holland">Steve M. Holland</name>
<name sortKey="Hsu, Amy P" sort="Hsu, Amy P" uniqKey="Hsu A" first="Amy P" last="Hsu">Amy P. Hsu</name>
<name sortKey="Townsley, Danielle" sort="Townsley, Danielle" uniqKey="Townsley D" first="Danielle" last="Townsley">Danielle Townsley</name>
<name sortKey="Winkler, Thomas" sort="Winkler, Thomas" uniqKey="Winkler T" first="Thomas" last="Winkler">Thomas Winkler</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Bigley, Venetia" sort="Bigley, Venetia" uniqKey="Bigley V" first="Venetia" last="Bigley">Venetia Bigley</name>
</noRegion>
<name sortKey="Collin, Matthew" sort="Collin, Matthew" uniqKey="Collin M" first="Matthew" last="Collin">Matthew Collin</name>
<name sortKey="Dickinson, Rachel E" sort="Dickinson, Rachel E" uniqKey="Dickinson R" first="Rachel E" last="Dickinson">Rachel E. Dickinson</name>
</country>
<country name="Norvège"><region name="Østlandet"><name sortKey="Aukrust, P L" sort="Aukrust, P L" uniqKey="Aukrust P" first="P L" last="Aukrust">P L Aukrust</name>
</region>
<name sortKey="Nord Y, Ingvild" sort="Nord Y, Ingvild" uniqKey="Nord Y I" first="Ingvild" last="Nord Y">Ingvild Nord Y</name>
</country>
</tree>
</affiliations>
</record>

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Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.

Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells.

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